Feature | Coffee | Kratom |
Origin | Ethiopia | Southeast Asia |
Active compound | Caffeine | Alkaloids |
Mechanism of action | Caffeine blocks adenosine receptors in the brain, and promotes wakefulness. | The alkaloids interact with opioid receptors in the brain and also interact with adrenergic, dopamine, and serotonin receptors. |
Available varieties | Arabica, Robusta, Blends, Specialty coffee | Red, Green, White, and other special blends |
Potential effects | Alertness [1] and concentration [2]. | Boost in energy [3] and manage fatigue [4] |
Legal status | The FDA considers caffeine, a primary component of coffee to be safe. Hence it’s legal in the US. | Kratom is legal at the federal level in the U.S.; however, it is regulated in some states and banned in 6. |
Cultural significance | A long-time staple in Western countries | It has been an integral part of Southeast Asian culture for centuries. |
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